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The Young Empowered Scientists for ContinUed Research Engagement (YES for CURE) Program is a 2.5-year training initiative for highly motivated underrepresented and disadvantaged high school and undergraduate students interested in pursuing a career in scientific research. Through engagement in mentored summer research projects, participation in an advanced scientific curriculum during the academic year, and year-round professional skills training, students will acquire scientific knowledge and technical skills, and increase their understanding of how to conduct biomedical research.